Logo tutelle Logo tutelle
Logo tutelle Logo tutelle


Sur ce site

Sur le Web du CNRS

Accueil du site > Équipes > Équipe 3 Enzymologie Moléculaire et Structurale


par Benjamin CHAGOT, Sophie RAHUEL-CLERMONT - 1er avril


  • , , BARBE S., , ANDRE I., TALFOURNIER F. (2019) Enzyme Active Site Loop Revealed as a Gatekeeper for Cofactor Flip by Targeted Molecular Dynamics Simulations and FRET-Based Kinetics. ACS catalysis 2019 Jan 3 9(2):1337–1346.


  • DORIVAL J., RISSER F., JACOB C., COLLIN S., DRAGER G., PARIS C., CHAGOT B., KIRSCHNING A., GRUEZ A., WEISSMAN K.J. (2018). Insights into a dual function amide oxidase/macrocyclase from lankacidin biosynthesis. Nat Commun. 2018 Sep 28;9(1):3998.
  • RAHUEL-CLERMONT S., TOLEDANO M.B. (2018). Parsing protein sulfinic acid switches. Nat Chem Biol. 2018 Nov;14(11):991-993.
  • MAIER T., WEISSMAN K.J. (2018). Editorial overview : Macromolecular assemblies: Assembly, dynamics and control of activity. Curr Opin Struct Biol. 2018 Apr;49:vi-vii.
  • CANABADY-ROCHELLE L.L.S. , SELMECZI K.,COLLIN S., PASC A., MUHR L. and BOSCHI-MULLER S. (2018). SPR screening of metal chelating peptides in a hydrolysate for their antioxidant properties. Food Chem. 239:478-485.
  • LEC J.C., BOUTSERIN S., MAZON H., MULLIERT G., BOSCHI-MULLER S., TALFOURNIER F. (2018) Unraveling the mechanism of cysteine persulfide formation catalyzed by 3-mercaptopyruvate sulfurtransferases. ACS Catalysis, 8:2049–2059.
  • KRIZNIK A., YELEHE-OKUMA M, LEC JC, GROSHENRY G., LE CORDIER H, CHARRON C, QUINTERNET M, MAZON H, TALFOURNIER F, BOSCHI-MULLERT S, JOUZEAU JY, REBOUL P.(2019) CRD(SAT) Generated by pCARGHO: A New Efficient Lectin-Based Affinity Tag Method for Safe, Simple, and Low-Cost Protein Purification. Biotechnol J. 14(4):e1800214.
  • CARRASCO K, BOUFENZER A, JOLLY L, Le CORDIER H, WANG G, HECK AJ, CERWENKA A, VINOLO E, NAZABAL A, KRIZNIK A, LAUNAY P, GIBOT S, DERIVE M. (2018) TREM-1 multimerization is essential for its activation on monocytes and neutrophils. Cell Mol Immunol.


  • ROY O, DUMONTEIL G, FAURE S, JOUFFRET L, KRIZNIK A, TAILLEFUMIER C. (2017) Homogeneous and Robust Polyproline Type I Helices from Peptoids with Nonaromatic α-Chiral Side Chains. J Am Chem Soc. 2017 Sep 27;139(38):13533-13540.
  • JACOB C.,WEISSMAN K.J. (2017) Unpackaging the Roles of Streptomyces Natural Products. Cell Chem Biol. 19;24(10):1194-1195.
  • BERSWEILER A, D'AUTRÉAUX B, MAZON H, KRIZNIK A, BELLI G, DELAUNAY-MOISAN A, TOLEDANO MB, RAHUEL-CLERMONT S. (2017) A scaffold protein that chaperones a cysteine-sulfenic acid in H2O2 signaling. Nat Chem Biol. 13(8):909-915.
  • WEISSMAN K.J. (2017) Polyketide stereocontrol: a study in chemical biology. Beilstein J Org Chem. 13:348-371.


  • BRIAND L., MARCION G., KRIZNIK A., HEYDEL J.M., ARTUR Y., GARRIDO C., SEIGNEURIC R., NEIERS F. (2016) A self-inducible heterologous protein expression system in Escherichia coli. Sci Rep., 6:33037.
  • DORIVAL J.$, ANNAVAL T.$, RISSER F., COLLIN S., ROBLIN P., JACOB C., GRUEZ A.*, CHAGOT B.* and WEISSMAN K.J.* (2016) Characterization of intersubunit communication in the virginiamycin trans-acyl transferase polyketide synthase. J. Am. Chem. Soc. 138: 4155-4167.
  • ROMERO E., MOUSSODIA R.O., KRIZNIK A., WENGER E., ACHERAR S., JAMART-GREGOIRE B. (2016). Spontaneous Self-Assembly of Fully Protected Ester 1:1 [α/α-Nα-Bn-hydrazino] Pseudodipeptides into a Twisted Parallel β-Sheet in the Crystal State. J Org Chem., 19:9037-9045.
  • GUERIN J., KRIZNIK A., RAMALANJAONA N., LE ROUX Y. and GIRARDET J.M. (2016). Interaction between dietary bioactive peptides of short length and bile salts in submicellar or micellar state. Food Chemistry, 209: 114–122.
  • WEISSMAN K. J. (2016). Genetic engineering of modular PKSs: from combinatorial biosynthesis to synthetic biology. Natural product reports, 33: 203-230.


  • ANNAVAL T., PARIS C., LEADLAY P. F., JACOB C.* and WEISSMAN K. J.* (2015). Evaluating ketoreductase exchanges as a means of rationally altering polyketide stereochemistry. ChemBioChem, 16: 1357-1364.
  • BOUKHENOUNA S., MAZON H., BRANLANT G., JACOB C., TOLEDANO M. B. and RAHUEL-CLERMONT S.* (2015). Evidence that glutathione and the glutathione system efficiently recycle 1-cys sulfiredoxin in vivo. Antioxidants & redox signaling, 22: 731-743.
  • FONTE C., GRUEZ A., GHISLIN S. and FRIPPIAT J. P. (2015). The urodele amphibian Pleurodeles waltl has a diverse repertoire of immunoglobulin heavy chains with polyreactive and species-specific features. Developmental and comparative immunology, 53: 371-384. 
  • GAND A.$,SELME-ROUSSEL L.$, COLLIN S., BRANLANT G., JACOB C. and BOSCHI-MULLER S.* (2015). Biochemical and functional characterization of a periplasmic disulfide oxidoreductase from Neisseria meningitidis essential for meningococcal viability. The Biochemical journal, 468: 271-282.
  • WEISSMAN K. J. (2015). Uncovering the structures of modular polyketide synthases. Natural product reports, 32: 436-453.
  • WEISSMAN K. J. (2015). The structural biology of biosynthetic megaenzymes. Nature chemical biology, 11: 660-670.  J Biol Chem. 2015 Feb 6;290(6):3836-49. PMID: 25525268


  • BOSCHI-MULLER S. and BRANLANT G. (2014). Methionine sulfoxide reductase: chemistry, substrate binding, recycling process and oxidase activity. Bioorganic chemistry, 57: 222-230.
  • DAVISON J., DORIVAL J., RABEHARINDRANTO H., MAZON H., CHAGOT B.*, GRUEZ A.* and WEISSMAN K.J.* (2014). Insights into the function of trans-acyl transferase polyketide synthases from the SAXS structure of a complete module. Chemical Science 5: 3081-3095.
  • DENONCIN K., VERTOMMEN D., ARTS I. S., GOEMANS C. V., RAHUEL-CLERMONT S., MESSENS J. and COLLET J. F. (2014). A new role for Escherichia coli DsbC protein in protection against oxidative stress. The Journal of biological chemistry, 289: 12356-12364.
  • KRIZNIK A., BOSCHI-MULLER S. and BRANLANT G.* (2014). Kinetic evidence that methionine sulfoxide reductase A can reveal its oxidase activity in the presence of thioredoxin. Archives of biochemistry and biophysics, 548: 54-59.