Université de Lorraine
CNRS
École Doctorale BIOSE
Contact
Intranet
Réservation des équipements

team RNA/P

Leaders:

B. CHARPENTIER

X. MANIVAL

TEAM RNA/P

RNA, RNP

Presentation

Welcome to the dedicated page for our molecular biology and RNA research team. Our scientific activity focuses on the fundamental molecular mechanisms underlying cellular biology, with a particular emphasis on RNA components. With several decades of experience, our team is recognized for its significant contributions in areas such as RNA maturation, post-transcriptional modification of RNA, and the biogenesis of RNA-protein complexes, also known as Ribonucleoproteins (RNPs).

Distinctiveness of Our Work: Multidisciplinary Approach and Clinical Implications

The distinctiveness of our work lies in our multidisciplinary approach. We employ a range of techniques, including genetic screening and linkage analyses, transcriptomics, proteomics, molecular genetics, cellular and molecular biology, biochemistry, and atomic-scale structural studies. Recently, we have expanded our activities to include clinical studies, collaborating with local health projects such as RHU FIGHT-HF and LUE IMPACT Geenage. We have also invested in the valorization of our fundamental research data, leading to pre-maturation projects in collaboration with SATT SAYENS, some of which have resulted in patents or are in the process of being patented ([]).

Affiliations and Scientific Networks

Our team is a member of the thematic group sifrARN (Structure, Integration, Function, and Reactivity of RNA) within the French Society of Biochemistry and Molecular Biology (SFBBM) and is a participant in the GDR RNA (Research Group 2083) ‘RNA as a tool and a target for medicinal chemistry and chemical biology.’ Additionally, we are an integral part of the ProteinLorraine network, bringing together a dozen laboratories affiliated with six scientific poles at the University of Lorraine.

Current Research Themes

Currently, our team’s research themes revolve around the biogenesis of Ribonucleoproteins (RNPs) and their involvement in normal conditions, adaptation to stress situations, as well as their role in pathologies. This research is particularly linked to local programs in clinical and translational research (IHU, FHU, LUE iSITE).

Affymetrix Station

Cell culture

epifluorescence

FPLC

Key Research Projects

UsnRNP: small nuclear ribonucleoprotein;

C/D sno/scaRNP : box C/D small nucleolar/small cajal RNP;

miRNP: microribonucleoproteins;

SRP: Signal Recognition Particle;

lncRNA ANRIL: Long Non-coding RNA ANRIL (Antisense Non-coding RNA in the INK4 Locus).

1. Assembly of RNA-Protein Macrocomplexes:

2. Identification of the Function of Orphan snoRNAs:

    • Study of Snord116: In-depth characterization of orphan snoRNAs from the Snord116 family, with a focus on their role in Prader-Willi Syndrome and the development of potential therapies. (hal-03481280).

3. Connections between Assembly Machineries:

    • snoRNP/miRNP Connection: Investigation of links between snoRNP and miRNP biogenesis, especially the formation of RPAP3/TRBP complexes. (hal-03583324).
    • Ribosomes and SRP: Exploration of the coordination between ribosome and SRP biogenesis to understand the connections between these two essential cellular nanomachines

4. RNP Biogenesis and Nuclear Condensates

    • Nucleolus: Study of the impact of the functional state of nucleoli on SRP biogenesis and vice versa.
    • Cajal Bodies (CB): Characterization of the effects of oxidative stress on the composition and function of CB.

5. Action of miRNA in a Heterologous Context:

    • Interaction of fecal miRNA with the microbiota: Collaboration with external teams to study the mode of action of fecal miRNA in a heterologous biological context, particularly their impact on microbiota composition.

6. Functional Dissection of the lncRNA ANRIL:

    • Modulation of histone marks, nuclear topology, and alternative splicing: Functional characterization of ANRIL and the development of potential therapeutic molecules. (hal-01715217 ; hal-03202552).

7. Functional Study of the lncRNA LEF1-AS1:

    • Associations with heart failure, aging, and cholesterol metabolism: Characterization of the molecular mechanisms linking LEF1-AS1 to these phenomena and identification of involved domains.

8. Transcriptome Adaptation in Response to Stress:

    • Regulation of alternative splicing (AS): Study of mechanisms regulating AS in response to thermal or oxidative stress, with a focus on modulating AS of transcripts from the gamma-glutamyl transferase (GGT-1) gene.

Members

AIGUEPERSE Christelle

Ingénieure d’études, CNRS

Projets : stress et épissage alternatif

Biographie

Bureau : Biopôle
Contacts
AYADI Lilia
Photo
Ingénieure détudes, CNRS

Projets

Biographie

Bureau : Biopôle
Contacts
BEHM-ANSMANT Isabelle
 
Chargée de recherche, CNRS

Projets : Alternative splicing, stress and pathologies

Biographie :

PhD in Biochemistry and Molecular Biology, Université H. Poincaré, Nancy, France (2004) on RNA post-transcriptional modifications.
Post-doc (2004-2006) European Molecular Biology Laboratory, Heidelberg, Germany, Lab of Elisa Izaurralde on post-transcriptional regulation of gene expression (NMD, miRNA).
Post-doc (2006-2007) Max Planck Institute for Developmental Biology, Tuebingen, Germany, Lab of Elisa Izaurralde on post-transcriptional regulation of gene expression (NMD, miRNA).
CNRS researcher (2007-present).
Accreditation to supervise research (HDR, habilitation à diriger les recherches), Lorraine University (UL), Nancy, France (2016).
Bureau : Biopôle
Contacts
BRANLANT Christiane
Photo
Directrice de recherche émérite, CNRS

Projets

Biographie

Bureau : Biopôle
Contacts
CAPELLE Hélène
Assistante ingénieure, CNRS

Projets

Biographie

Bureau : Biopôle
Contacts
CHAGOT Marie-Eve
Photo
Ingénieure d’études, CNRS

Projets

Biographie

Bureau : Biopôle
Contacts
CHARPENTIER Bruno

Professeur, Université de Lorraine

Projets : RNP function and biogenesis

Biographie :

PhD in Biochemistry and Molecular Biology at Université H. Poincaré, Nancy, France (1994), in the laboratory of Christiane Branlant.

Post-doc (1994-97) at HHMI Brandeis University, USA, in the laboratory of Michael Rosbash.

Accreditation to supervise research (HDR, habilitation à diriger les recherches), Université H. Poincaré, Nancy, France (2005).

Professor of Molecular Biology at the Faculty of Sciences & Technologies, Université de Lorraine (UL).

Deputy Director of the Biology and Health Centre (pôle UL Biologie Médecine Santé, 2012-2022).

co-head of the team RNA-RNP (2008-present).

Deputy Director (2013-2023) and Head (2024-present) of the IMoPA laboratory.

Bureau : Biopôle

Contacts


 

 

 
CHARRON Christophe
Photo
Ingénieur de Recherche, CNRS

Projets

Biographie

Bureau : Biopôle
Contacts
FLAYAC Justine
Photo
Assistante Ingénieure, CNRS

Projets

Biographie

Bureau : Biopôle
Contacts
ISSA Amani
Photo
Chercheuse contractuelle

Projets

Biographie

Bureau : Biopôle
Contacts
LABIALLE Stéphane
Photo
Maître de Conférence, Université de Lorraine

Projets

Biographie

Bureau : Biopôle
Contacts
MAENNER Sylvain
Photo
Maître de Conférence, Université de Lorraine

Projets

Biographie

Bureau : Biopôle
Contacts
MANIVAL Xavier
Photo
Directeur de Recherche, CNRS

Projets

Biographie

Bureau : Biopôle
Contacts
MASSENET Séverine
Chargée de recherche, CNRS

Projets : Biogenesis of H/ACA RNP and Signal Recognition Particle 

Biographie :

PhD in Biochemistry and Molecular Biology, University of H. Poincaré, Nancy, France (1999) on RNA modifications.

Post-doc (2000-2002) HHMI Philadelphia, USA, lab of Gideon Dreyfuss, on the Survival of the SMN complex.

CNRS researcher (2002-present).

Accreditation to supervise research (HDR, Habilitation à diriger les recherches), Lorraine University, Nancy, France (2014).

Member of the administrative board of the SFBBM (French Society of Biochemistry and Molecular Biology) (2019-present).

Bureau : Biopôle
Contacts
RAORANE Kasturi
Photo
Doctorante

Projets

Biographie

Bureau : Biopôle
Contacts
REDERSTORFF Mathieu
Maître de Conférence, Université de Lorraine

Projets : Maturation, Assemblage et fonctions des RNPs

Responsable du Master 2 “RNAES”

Biographie :

2007 – 2010         Postdoc: Division of Genomics and RNomics, Innsbruck Medical University

                                Identification de nouveaux petits ARNs non codants.

2006                      Postdoc : INSERM, U 582, Institut de Myologie, Hôpital Pitié-Salpêtrière, Paris, France

                               Analyse de la souris invalidée pour le gène de la Sélénoprotéine N.

2002 – 2006         PhD: CNRS, UPR 9002, IBMC, Strasbourg, France

Etude du rôle du sélénium et de la sélénoprotéine N dans les pathologies musculaires.

2001 – 2002         MSc: CNRS, UPR 9002, IBMC, Strasbourg, France

Construction d´outils pour la caractérisation fonctionnelle de la Sélénoprotéine N.

Bureau : Biopôle
Contacts
ROBERT Anne
Photo
Technicienne de Recherche, Université de Lorraine

Projets

Biographie

Bureau : Biopôle
Contacts
SANCHEZ Aymeric
Photo
Chercheur contractuel

Projets

Biographie

Bureau : Biopôle
Contacts
SARDINI Lucas
Photo
Doctorant

Projets

Biographie

Bureau : Biopôle
Contacts
VIRCIGLIO Camille
Photo
Doctorante

Projets

Biographie

Bureau : Biopôle
Contacts
VISVIKIS Athanase
Photo
Professeur, Université de Lorraine

Projets

Biographie

Bureau : Biopôle
Contacts

Funding

Legal notices

Credits

©  2024 Ingénierie Moléculaire Cellulaire & Physiopathologie. Built using WordPress and the Mesmerize theme