Introduction words:

The “Rhine-knee Regiomeeting on structural biology” has brought together every year for 35 years structural biologists, most of them young researchers under the guidance of experienced scientists. This unique trinational event was created in 1987 by three biological crystallography laboratories in Strasbourg, Freiburg and Basel. It has since gone far beyond the limits of the upper Rhine Valley and has become very popular in this domain. It is aimed primarily at young researchers and offers them the opportunity to share their results through oral presentations, often for the first time and in front of an international audience from both basic research covering all fields of integrative structural biology and the pharmaceutical industry, all in a friendly and relaxed atmosphere. This recurring annual meeting facilitates the exchange of scientific, technical and technological skills of young researchers.

Photo of Rhine-knee Regiomeeting participants near the lake of Gérardmer.
The next RegioMeeting for Structural Biology will take place in September/October 2023 in Switzerland.

Dr. Frédérique Favier Cristallographie, Résonance Magnétique et Modélisations (CRM2) Frederique.Favier@univ-lorraine.fr Dr. Claude Didierjean Cristallographie, Résonance Magnétique et Modélisations (CRM2) Claude.Didierjean@univ-lorraine.fr Dr. François Dehez Laboratoire de Physique et Chimie Théorique (LPCT) Francois.Dehez@univ-lorraine.fr Dr. Xavier Manival Ingénierie Moléculaire et Physiopathologie Articulaire (IMoPA) Xavier.Manival@univ-lorraine.fr
Mme Séverine Bonenberger (Severine.Bonenberger@univ-lorraine.fr) Mme Christelle Kondratow (Christelle.Kondratow@univ-lorraine.fr) Mme Morgane Viloria : (morgane.viloria@univ-lorraine.fr)
Contact for the congress: regiomeeting2022-contact@univ-lorraine.frWebsite designed by Benjamin Chagot (IMoPA)

Several renowned researchers were invited to present the promise of current structural biology methods. Dr. Sandra Cowen-Jacob (Novartis, Basel) recounted 20 years of pharmaceutical research that led to the discovery of new and effective treatments for a form of leukemia. Dr. Sergei Grudinin (LJK CNRS, Grenoble) explained the recent exceptional advances in structure prediction. Pr. Alexandre Urzhumtsev (IGBMC, Strasbourg) illustrated how methodological developments improve the exploitation of experimental methods. Prof. Dr. Werner Kühlbrandt (Max Planck Institute for Biophysics, Frankfurt) described some of the remarkable results his team recently obtained in cryo-electron microscopy to investigate the structure of the respiratory chain complexes that generate the proton gradient necessary for ATP production.

This event was supported by many institutional and private partners. In particular, the Franco-German University generously funded the participation of many young researchers to contribute to their training, allowing doctoral students to hold their first international talk. About thirty conferences were presented. Two prizes were awarded to the best of them, to Ms. Nele Dierlamm (IFIB, University of Tübingen) and to Mr. Elia Agustoni (Biozentrum, University of Basel).

Link to registration : http://regiomeeting2022-ins.event.univ-lorraine.fr/regio22_insc.php

Fees for student:140€ HT
Fees for academic (AFC/SFB members/non members):250€/290€ HT
Fees for non-academic:450€ HT

The registration fees include access to the congress area, exhibition hall and conferences, as well as coffee breaks, lunches (from Wednesday to Friday), the cocktail, and the gala dinner.

Call for Abstracts Template:
  • Please download the template abstract (as a word document) here.
  • Please submit your abstracts with your registration.
  • Abstract submission deadline: September 16, 2022.
  • Please keep in mind that the presentation slots are 15 min (12 min talk + 3 min questions) and 10 min in the industry session.
  • A 5-minute “flash-talk” session will allow participants who have no other presentation time to introduce their research themes in order to facilitate discussions with the community.
  • Speakers are asked to emphasize techniques and methods used in their study as well as encountered problems.


Social Program
  • Hike to the Tour de Merelle
  • Tree climbing
  • electric mountain bike
  • self-guided hike
Conference Location

By Train:

SNCF-TGV station at Remiremont (88 200) or at Epinal (88 000). Then, take a taxi to Gérardmer (30-40 min drive).

By Car:

From Nancy, take the N57 to Epinal and the D11 to Gérardmer (1 hour 30 minutes drive).

From Strasbourg, take the A35 to Colmar and the D417 to Gérardmer (1 hour 50 minutes drive).

From Basel, take the A35 in the direction of Colmar and the D83 and D417 to Gérardmer (1 hour 40 minutes drive).

By Plane:

From EuroAirport Basel-Mulhouse-Freiburg take a taxi to Géradmer (1 hour 40 minutes drive)

Day 1: Wednesday 5th October
2:00 - 4:30 pmArrival and check-in. Welcome address: Hôtel Beau Rivage, Esplanade du Lac, 88400 Gérardmer
4:30 - 4:45 pmWelcome words
4:45 - 5:45 pmKeynote Lecture 1: Dr. Sandra Jacob (Novartis), A drug discovery journey: Targeting Abl kinase to treat Chronic Myelogenous Leukemia. (Chairman: Dr. F. Favier, CRM2, Nancy).
5:45 - 7:30 pmSession 1: Structural properties of nucleic acids and enzymes (Chairman: Pr. B. Charpentier, IMoPA, Nancy)
5:45 - 6:00 pmG. Papai (IGBMC-CBI), Université de Strasbourg : SAGA saga or, how TBP is deposited on DNA.
6:00 - 6:15 pmB. Masquida (GMGM, Université de Strasbourg): Anticodon-like loop-mediated dimerization in the crystal structures of HdV-like CPEB3 ribozymes.
6:15 - 6:30 pmE. Bignon (LPCT, Université de Lorraine): Modeling the dynamics and reactivity of nucleic acids to understand and fight viral infections.
6:30 - 6:45 pmL. Morette (IAM, Université de Lorraine): Biochemical and structural characterization of the iota class GST from the cyanobacterium Synechocystis sp. PCC6803.
6:45 - 7:00 pmP. Havlickova(DC, University of South Bohemia): Crystal strucure of smolstatin - protease inhibitor from the myxozoan parasite Sphaerospora molnari.
7:00 - 7:15 pmA.C. Stasiak (IFIB, University of Tübingen): Crystal structures of Tannerella Forsythia sugar kinases with different specificities in complex with their substrates.
7:15 - 7:30 pmN. Dierlamm (IFIB, Université of Tübingen): Cell wall hydrolase MUPG reveals an inter-molecular active site.
7:30 - 7:45 pmD. Teboul (Cytiva): Cytiva Company Introduction.
8:00 - 9:30 pmAperitif, Diner
9:30 - 11:00 pmNetworking (1 coupon)
Day 2: Thursday 6th October
7:00 - 8:30 amBreakfast
8:30 - 10:15 amSession 2: Deep learning in biological and health sciences (Chairman: Dr. M. Tarek, LPCT, Nancy)
8:30 - 9:30 amKeynote Lecture 2: Dr Serge Grudinin (LJK CNRS, Grenoble, France) Deep learning in the post-protein structure prediction era: new horizons for structural biology.
9:30 - 9:45 amH. Chen (LPCT, Université de Lorraine): Chasing collective variables using temporal data driven strategies
9:45 - 10:00 amY. Kacher (LPCT, Université de Lorraine): Proteins conformational space investigation: a machine learning approach to uncover missing intermediates
10:00 - 10:15 amD. Wiczew (LPCT, CNRS- Université de Lorraine): Curiosity sampling: enhancing exploration of protein conformational space using machine learning
10:15 - 10:30 amL. Loss (Rigaku)
10:30 - 11:00 amBreak/The group photo
11:00 - 12:30 amSession 3: Structural properties and analysis of large macromolecular complexes / (Chairman: Dr. B. Douzi, DynAMic, Nancy)
11:00 - 11:15 amV. Loeffelholz (IGBMC-CBI, Université de Strasbourg): Molecular basis of mRNA Kozak sequence recognition by the ribosome
11:15 - 11:30 amW-C. Kao (CIBSS, University of Freiburg): High resolution cryo-EM structure of the actinobacterial respiratory supercomplex
11:30 - 11:45 amS. Holvec (IGBMC-CBI, Université de Strasbourg): Chemical modifications inside the human ribosome as seen in the high-resolution structure
11:45 - 12:00 amR. Maffo-Woullefack (DynAMic, Université de Lorraine): Structural and functional analysis of OrfG, a central component of Type IV Secretion system of ICESt3
12:00 - 1:15 pmLunch
1:30 - 4:00 pmHike / Electric mountain bike
4:00 - 4:30 pmPause
4:30 - 5:15 pmSession 4: Crystallization methods for serial crystallography experiments (Chairman: Dr C. Sauter, IBMC, Strasbourg)
4:30 - 4:45 pmP. Pachl (IBMC, CNRS): Rutinosidase – Labyrinthine journey for X-ray structure
4:45 - 5:00 pmB. Gotthard (PSI, Villigen): Blue-light activated state of a LOV photoreceptor captured by time-resolved serial crystallography
5:00 - 5:15 pmG. Khusainov (PSI, Villigen): CO2 fixation by RuBisCO involves a labile magnesium
5:15 - 5:30 pmE. Martin (Bruker)
5:30 - 7:15 pmSession 5: Methods and software developments for structural biology: recent advances (Chairman: Pr. B. Guillot, CRM2, Nancy)
5:30 - 6:30 pmKeynote Lecture 3: Pr. Alexandre Urzhumtsev (IGBMC, Université de Strabourg, France): Analytic representation of inhomogeneous resolution density maps.
6:30 - 6:45 pmT. Malliavin (LPCT, Université de Lorraine): In silico investigation of physical models underlying the interaction of botulinum neurotoxins with the synaptic vesicle membrane
6:45 - 7:00 pmE. Mocchetti (CRM2, Université de Lorraine Nancy): Electrostatic properties of biological macromolecules from transferred experimental electron density of small molecules
7:00 - 7:15 pmM. Blazhynska (LPCT, Université de Lorraine): Calculation of binding affinities for SARS-CoV-2 variants with quantitative accuracy
7:15 - 7:30 pmA. Kravchenko (LORIA, Université de Lorraine): Optimizing scoring for ssRNA-protein docking models
7:30 - 8:00 pmGala Coktail
8:00 - 10:00 pmGala dinner
10:30 - 00:00 pmTheme evening (1 coupon)
Day 3: Friday 7th October
7:00 - 8:15 amBreakfast
8:15 - 8:30 amRoom check-out
8:30 - 10:00 amSession 6: Symbiosis of methods for determination of large-marcromolecular structures (Chairman: Prof. Dr. J.P. Abraham, Biozentrum, Switzerland)
8:30 - 9:30 amKeynote Lecture 4: Prof. Dr. Werner Kühlbrandt (MPI of Biophysics, Frankfurt, Germany): High-resolution cryoEM of membrane protein complexes.
9:30 - 9:45 amC. Barchet (IGBMC-CBI, Université de Strasbourg): Focused classification and refinements in high-resolution single particle cryo-EM analysis
9:45 - 10:00 amL. Frechin (IGBMC-CBI, Université de Strasbourg): High-resolution cryo-EM performance comparison of two latest-generation cryo electron microscopes on the human ribosome
10:00 - 10:15 amD. Singh (Thermo Fisher Scientific): Bringing Cryo-Electron Microscopy (Cryo-EM) to every lab- Introducing Tundra
10:15 - 10:45 amBreak
10:45 - 12:00 amSession 7: Receptors: signaling and membran proteins (Chairman: Dr. T. Malliavin, LPCT, Nancy)
10:45 - 11:00 amC. Fernandes (IMPMC, Sorbonne Université): Cryo–Electron microscopy unveils unique structural features of the human KIR2.1 channel
11:00 - 11:15 amD. Zuniga (IMPMC, Sorbonne Université): Structural and functional study of a human potassium channel, Kir2.1: mechanism and consequences of mutations
11:15 - 11:30 amK. VonMetz (IFIB, University of Tübingen): Structural characterization of Siglec-11 V-set
11:30 - 11:45 amE. Agustoni (Biozentrum, University of Basel): Structure and mechanism of Leptospira's virulence switch
11:45 - 12:00 amN. Rustmeier (IFIB, University of Tübingen): A Lectin from Polyomavirus with Paramount Specificity for the Forssman Antigen
12:00 - 12:15 pmConclusion / Presentation of the 2023 organizing team (hand-over of the "Regio belt")
12:15 - 1:45 pmLunch and Departure
1:45 - 2:00 pmAward of the two best conferences and Departure




Organisers :

Dr. Frédérique Favier            CRM2


Dr. Claude Didierjean           CRM2 Claude.Didierjean@univ-lorraine.fr
Dr. François Dehez LPCT Francois.Dehez@univ-lorraine.fr
Dr. Xavier Manival IMoPA Xavier.Manival@univ-lorraine.fr

Secrétariat :

Mme Séverine Bonenberger (Severine.Bonenberger@univ-lorraine.fr)

Mme Christelle Kondratow (Christelle.Kondratow@univ-lorraine.fr)


Keynotes :

Dr Sandra Jacob           Novartis (CH)

Registration (deadline 02.09.2022) : “LIEN VERS RESERVATION”


Day 1: Wednesday 5th October
2:30 – 5:30 pm Arrival and check-in. Welcome address: Hôtel Beau Rivage, Esplanade du Lac, 88400 Gérardmer
5:30 – 5:45 pm Welcome words
6:00 – 7:00 pm Keynote Lecture 1: Dr. Sandra Jacob (Novartis) Structural biology methods for understanding molecule/therapeutic target interactions
7:15 – 8:30 pm Diner
8:45 – 10:00 pm Session 1: Structural properties of Nucleic acids and enzymes
10:00 pm on Networking

Day 2: Thursday 6th October
7:00 – 8:30 am Breakfast
9:00 – 10:00 am Keynote Lecture 2:
10:00 – 10:30 am Session 2: Deep learning in biological and health sciences
10:30 – 11:00 am Break
11:00 – 12:30 am Session 3: Structural properties and analysis of large macromolecular complexes / Flash-talks
12:30 – 1:30 pm Lunch
2:00 – 5:00 pm Hikes / Visits
5:00 – 6:30 pm Session 4: Methods and software developments for structural biology: recent advances
6:30 – 8:00 pm Session 5: Crystallisation methods for serial crystallography experiments
8:00 – 8:30 pm Coktail de gala
8:30 – 10:30 pm Diner de gala
10:30 – 00:00 pm Theme evening

Day 3: Friday 7th October
7:00 – 8:30 am Breakfast
8:45 – 9:45 am Keynote Lecture 3:
9:45 – 10:30 am Session 6: Symbiosis of methods in determination of large-marcromolecular structures
10:30 – 11:00 am Break
11:00 – 12:30 am Session 7: Receptors: signaling and membrane proteins
12:30 – 1:00 pm Conclusion / Presentation of the 2023 organizing team (hand-over of the “Regio bell”)
1:00 – 2:30 pm Lunch and Departure

Trame Site Internet 35rd Rhine Regio Meeting