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35th RHINE-KNEE-REGIONAL MEETING ON STRUCTURAL BIOLOGY
Introduction words:
The « Rhine-knee Regiomeeting on structural biology » has brought together every year for 35 years structural biologists, most of them young researchers under the guidance of experienced scientists. This unique trinational event was created in 1987 by three biological crystallography laboratories in Strasbourg, Freiburg and Basel. It has since gone far beyond the limits of the upper Rhine Valley and has become very popular in this domain. It is aimed primarily at young researchers and offers them the opportunity to share their results through oral presentations, often for the first time and in front of an international audience from both basic research covering all fields of integrative structural biology and the pharmaceutical industry, all in a friendly and relaxed atmosphere. This recurring annual meeting facilitates the exchange of scientific, technical and technological skills of young researchers.
Photo of Rhine-knee Regiomeeting participants near the lake of Gérardmer.
The next RegioMeeting for Structural Biology will take place in September/October 2023 in Switzerland.
 Dr. Frédérique Favier
Cristallographie, Résonance Magnétique et Modélisations (CRM2)
Frederique.Favier@univ-lorraine.fr |
Dr. Claude Didierjean
Cristallographie, Résonance Magnétique et Modélisations (CRM2)
Claude.Didierjean@univ-lorraine.fr |
Dr. François Dehez
Laboratoire de Physique et Chimie Théorique (LPCT)
Francois.Dehez@univ-lorraine.fr |
Dr. Xavier Manival
Ingénierie Moléculaire et Physiopathologie Articulaire (IMoPA)
Xavier.Manival@univ-lorraine.fr |
| Secretariat: | ||
Mme Séverine Bonenberger (Severine.Bonenberger@univ-lorraine.fr) |
Mme Christelle Kondratow (Christelle.Kondratow@univ-lorraine.fr) |
Mme Morgane Viloria : (morgane.viloria@univ-lorraine.fr) |
| Contact for the congress: regiomeeting2022-contact@univ-lorraine.fr | Website designed by Benjamin Chagot (IMoPA) |
Link to registration : http://regiomeeting2022-ins.event.univ-lorraine.fr/regio22_insc.php
| Fees | |
| Fees for student: | 140€ HT |
| Fees for academic (AFC/SFB members/non members): | 250€/290€ HT |
| Fees for non-academic: | 450€ HT |
The registration fees include access to the congress area, exhibition hall and conferences, as well as coffee breaks, lunches (from Wednesday to Friday), the cocktail, and the gala dinner.
| Call for Abstracts Template: |
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| Social Program |
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| Conference Location |
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| Transport |
By Train: SNCF-TGV station at Remiremont (88 200) or at Epinal (88 000). Then, take a taxi to Gérardmer (30-40 min drive). |
By Car: From Nancy, take the N57 to Epinal and the D11 to Gérardmer (1 hour 30 minutes drive). From Strasbourg, take the A35 to Colmar and the D417 to Gérardmer (1 hour 50 minutes drive). From Basel, take the A35 in the direction of Colmar and the D83 and D417 to Gérardmer (1 hour 40 minutes drive). |
By Plane: From EuroAirport Basel-Mulhouse-Freiburg take a taxi to Géradmer (1 hour 40 minutes drive) |
| Day 1: Wednesday 5th October | |
| 2:00 – 4:30 pm | Arrival and check-in. Welcome address: Hôtel Beau Rivage, Esplanade du Lac, 88400 Gérardmer |
| 4:30 – 4:45 pm | Welcome words |
| 4:45 – 5:45 pm | Keynote Lecture 1: Dr. Sandra Jacob (Novartis), A drug discovery journey: Targeting Abl kinase to treat Chronic Myelogenous Leukemia. (Chairman: Dr. F. Favier, CRM2, Nancy). |
| 5:45 – 7:30 pm | Session 1: Structural properties of nucleic acids and enzymes (Chairman: Pr. B. Charpentier, IMoPA, Nancy) |
| 5:45 – 6:00 pm | G. Papai (IGBMC-CBI), Université de Strasbourg : SAGA saga or, how TBP is deposited on DNA. |
| 6:00 – 6:15 pm | B. Masquida (GMGM, Université de Strasbourg): Anticodon-like loop-mediated dimerization in the crystal structures of HdV-like CPEB3 ribozymes. |
| 6:15 – 6:30 pm | E. Bignon (LPCT, Université de Lorraine): Modeling the dynamics and reactivity of nucleic acids to understand and fight viral infections. |
| 6:30 – 6:45 pm | L. Morette (IAM, Université de Lorraine): Biochemical and structural characterization of the iota class GST from the cyanobacterium Synechocystis sp. PCC6803. |
| 6:45 – 7:00 pm | P. Havlickova(DC, University of South Bohemia): Crystal strucure of smolstatin – protease inhibitor from the myxozoan parasite Sphaerospora molnari. |
| 7:00 – 7:15 pm | A.C. Stasiak (IFIB, University of Tübingen): Crystal structures of Tannerella Forsythia sugar kinases with different specificities in complex with their substrates. |
| 7:15 – 7:30 pm | N. Dierlamm (IFIB, Université of Tübingen): Cell wall hydrolase MUPG reveals an inter-molecular active site. |
| 7:30 – 7:45 pm | D. Teboul (Cytiva): Cytiva Company Introduction. |
| 8:00 – 9:30 pm | Aperitif, Diner |
| 9:30 – 11:00 pm | Networking (1 coupon) |
| Day 2: Thursday 6th October | |
| 7:00 – 8:30 am | Breakfast |
| 8:30 – 10:15 am | Session 2: Deep learning in biological and health sciences (Chairman: Dr. M. Tarek, LPCT, Nancy) |
| 8:30 – 9:30 am | Keynote Lecture 2: Dr Serge Grudinin (LJK CNRS, Grenoble, France) Deep learning in the post-protein structure prediction era: new horizons for structural biology. |
| 9:30 – 9:45 am | H. Chen (LPCT, Université de Lorraine): Chasing collective variables using temporal data driven strategies |
| 9:45 – 10:00 am | Y. Kacher (LPCT, Université de Lorraine): Proteins conformational space investigation: a machine learning approach to uncover missing intermediates |
| 10:00 – 10:15 am | D. Wiczew (LPCT, CNRS- Université de Lorraine): Curiosity sampling: enhancing exploration of protein conformational space using machine learning |
| 10:15 – 10:30 am | L. Loss (Rigaku) |
| 10:30 – 11:00 am | Break/The group photo |
| 11:00 – 12:30 am | Session 3: Structural properties and analysis of large macromolecular complexes / (Chairman: Dr. B. Douzi, DynAMic, Nancy) |
| 11:00 – 11:15 am | V. Loeffelholz (IGBMC-CBI, Université de Strasbourg): Molecular basis of mRNA Kozak sequence recognition by the ribosome |
| 11:15 – 11:30 am | W-C. Kao (CIBSS, University of Freiburg): High resolution cryo-EM structure of the actinobacterial respiratory supercomplex |
| 11:30 – 11:45 am | S. Holvec (IGBMC-CBI, Université de Strasbourg): Chemical modifications inside the human ribosome as seen in the high-resolution structure |
| 11:45 – 12:00 am | R. Maffo-Woullefack (DynAMic, Université de Lorraine): Structural and functional analysis of OrfG, a central component of Type IV Secretion system of ICESt3 |
| 12:00 – 1:15 pm | Lunch |
| 1:30 – 4:00 pm | Hike / Electric mountain bike |
| 4:00 – 4:30 pm | Pause |
| 4:30 – 5:15 pm | Session 4: Crystallization methods for serial crystallography experiments (Chairman: Dr C. Sauter, IBMC, Strasbourg) |
| 4:30 – 4:45 pm | P. Pachl (IBMC, CNRS): Rutinosidase – Labyrinthine journey for X-ray structure |
| 4:45 – 5:00 pm | B. Gotthard (PSI, Villigen): Blue-light activated state of a LOV photoreceptor captured by time-resolved serial crystallography |
| 5:00 – 5:15 pm | G. Khusainov (PSI, Villigen): CO2 fixation by RuBisCO involves a labile magnesium |
| 5:15 – 5:30 pm | E. Martin (Bruker) |
| 5:30 – 7:15 pm | Session 5: Methods and software developments for structural biology: recent advances (Chairman: Pr. B. Guillot, CRM2, Nancy) |
| 5:30 – 6:30 pm | Keynote Lecture 3: Pr. Alexandre Urzhumtsev (IGBMC, Université de Strabourg, France): Analytic representation of inhomogeneous resolution density maps. |
| 6:30 – 6:45 pm | T. Malliavin (LPCT, Université de Lorraine): In silico investigation of physical models underlying the interaction of botulinum neurotoxins with the synaptic vesicle membrane |
| 6:45 – 7:00 pm | E. Mocchetti (CRM2, Université de Lorraine Nancy): Electrostatic properties of biological macromolecules from transferred experimental electron density of small molecules |
| 7:00 – 7:15 pm | M. Blazhynska (LPCT, Université de Lorraine): Calculation of binding affinities for SARS-CoV-2 variants with quantitative accuracy |
| 7:15 – 7:30 pm | A. Kravchenko (LORIA, Université de Lorraine): Optimizing scoring for ssRNA-protein docking models |
| 7:30 – 8:00 pm | Gala Coktail |
| 8:00 – 10:00 pm | Gala dinner |
| 10:30 – 00:00 pm | Theme evening (1 coupon) |
| Day 3: Friday 7th October | |
| 7:00 – 8:15 am | Breakfast |
| 8:15 – 8:30 am | Room check-out |
| 8:30 – 10:00 am | Session 6: Symbiosis of methods for determination of large-marcromolecular structures (Chairman: Prof. Dr. J.P. Abraham, Biozentrum, Switzerland) |
| 8:30 – 9:30 am | Keynote Lecture 4: Prof. Dr. Werner Kühlbrandt (MPI of Biophysics, Frankfurt, Germany): High-resolution cryoEM of membrane protein complexes. |
| 9:30 – 9:45 am | C. Barchet (IGBMC-CBI, Université de Strasbourg): Focused classification and refinements in high-resolution single particle cryo-EM analysis |
| 9:45 – 10:00 am | L. Frechin (IGBMC-CBI, Université de Strasbourg): High-resolution cryo-EM performance comparison of two latest-generation cryo electron microscopes on the human ribosome |
| 10:00 – 10:15 am | D. Singh (Thermo Fisher Scientific): Bringing Cryo-Electron Microscopy (Cryo-EM) to every lab- Introducing Tundra |
| 10:15 – 10:45 am | Break |
| 10:45 – 12:00 am | Session 7: Receptors: signaling and membran proteins (Chairman: Dr. T. Malliavin, LPCT, Nancy) |
| 10:45 – 11:00 am | C. Fernandes (IMPMC, Sorbonne Université): Cryo–Electron microscopy unveils unique structural features of the human KIR2.1 channel |
| 11:00 – 11:15 am | D. Zuniga (IMPMC, Sorbonne Université): Structural and functional study of a human potassium channel, Kir2.1: mechanism and consequences of mutations |
| 11:15 – 11:30 am | K. VonMetz (IFIB, University of Tübingen): Structural characterization of Siglec-11 V-set |
| 11:30 – 11:45 am | E. Agustoni (Biozentrum, University of Basel): Structure and mechanism of Leptospira’s virulence switch |
| 11:45 – 12:00 am | N. Rustmeier (IFIB, University of Tübingen): A Lectin from Polyomavirus with Paramount Specificity for the Forssman Antigen |
| 12:00 – 12:15 pm | Conclusion / Presentation of the 2023 organizing team (hand-over of the « Regio belt ») |
| 12:15 – 1:45 pm | Lunch and Departure |
| 1:45 – 2:00 pm | Award of the two best conferences and Departure |
Dr. Frédérique Favier CRM2
Frederique.Favier@univ-lorraine.fr
Dr. Claude Didierjean CRM2
Claude.Didierjean@univ-lorraine.fr
Dr. François Dehez LPCT
Francois.Dehez@univ-lorraine.fr
Dr. Xavier Manival IMoPA
Xavier.Manival@univ-lorraine.fr Mme Séverine Bonenberger (Severine.Bonenberger@univ-lorraine.fr)
Mme Christelle Kondratow (Christelle.Kondratow@univ-lorraine.fr)
Dr Sandra Jacob Novartis (CH)
Host Institution :
Sponsors:
Day 1: Wednesday 5th October
2:30 – 5:30 pm Arrival and check-in. Welcome address: Hôtel Beau Rivage, Esplanade du Lac, 88400 Gérardmer
5:30 – 5:45 pm Welcome words
6:00 – 7:00 pm Keynote Lecture 1: Dr. Sandra Jacob (Novartis) Structural biology methods for understanding molecule/therapeutic target interactions
7:15 – 8:30 pm Diner
8:45 – 10:00 pm Session 1: Structural properties of Nucleic acids and enzymes
10:00 pm on Networking
Day 2: Thursday 6th October
7:00 – 8:30 am Breakfast
9:00 – 10:00 am Keynote Lecture 2:
10:00 – 10:30 am Session 2: Deep learning in biological and health sciences
10:30 – 11:00 am Break
11:00 – 12:30 am Session 3: Structural properties and analysis of large macromolecular complexes / Flash-talks
12:30 – 1:30 pm Lunch
2:00 – 5:00 pm Hikes / Visits
5:00 – 6:30 pm Session 4: Methods and software developments for structural biology: recent advances
6:30 – 8:00 pm Session 5: Crystallisation methods for serial crystallography experiments
8:00 – 8:30 pm Coktail de gala
8:30 – 10:30 pm Diner de gala
10:30 – 00:00 pm Theme evening
Day 3: Friday 7th October
7:00 – 8:30 am Breakfast
8:45 – 9:45 am Keynote Lecture 3:
9:45 – 10:30 am Session 6: Symbiosis of methods in determination of large-marcromolecular structures
10:30 – 11:00 am Break
11:00 – 12:30 am Session 7: Receptors: signaling and membrane proteins
12:30 – 1:00 pm Conclusion / Presentation of the 2023 organizing team (hand-over of the « Regio bell »)
1:00 – 2:30 pm Lunch and Departure